The Troubling Function of Glyphosate in COVID-19

This text was beforehand revealed February 28, 2021, and has been up to date with new info.

On this interview, Stephanie Seneff, Ph.D., a senior analysis scientist at MIT, critiques the well being impacts of glyphosate. She has simply completed writing a e-book about glyphosate referred to as “Poisonous Legacy: How the Weedkiller Glyphosate is Destroying Our Well being and the Surroundings,” which is predicted to be revealed in June 2021.

For years, glyphosate was assumed protected and claims of toxicity had been vehemently denied. However in recent times, research on glyphosate have been demonstrating toxicity even at very low ranges. Seneff additionally believes glyphosate publicity could also be a key participant in instances of extreme COVID-19, which we’ll unravel on this interview.

Glyphosate’s Mechanism of Motion

The “gly” in glyphosate truly stands for the amino acid glycine. The glycine amino acid in glyphosate has a methylphosphonate group hooked up to its nitrogen atom, which is answerable for its results and toxicity.

After learning the analysis literature on glyphosate, Seneff has reached the conclusion that your physique generally substitutes glyphosate for the amino acid glycine when it’s setting up proteins, and this could have devastating penalties in some instances. The proteins created with glyphosate as a substitute of glycine merely do not work as a result of glyphosate is far bigger than glycine and likewise negatively charged, and because of this this alters necessary bodily traits.

Monsanto’s personal analysis, courting again to the late Nineteen Eighties, exhibits that glyphosate accumulates in varied tissues, regardless that they declare it would not.1 The Monsanto researchers proposed that it was “integrated into” the proteins within the tissues. This isn’t broadly appreciated, even within the pure well being group.

Now, when you have a distorted analog of glycine (within the type of glyphosate), the protein constructed from it isn’t going to work prefer it’s alleged to. In her e-book, Seneff particulars the amino acids in proteins which are most prone to break due to what she calls a “glyphosate prone motif.”

“It is actually fascinating biology and so terrifying whenever you consider the potential penalties, if I am proper,” she says. “It matches so effectively with all of the illnesses which are going up dramatically in our society that I actually suppose I am onto one thing enormous right here.”

An fragrant amino acid referred to as EPSP synthase is a vital enzyme that nearly absolutely will get disrupted by glyphosate by means of this mechanism of substituting for glycine. This will get a bit technical, however it will be important. The plant model of EPSP synthase binds a phosphate group in its substrate phosphoenolpyruvate at a website the place there’s a highly-conserved glycine residue (extremely conserved normally signifies that it’s vital for correct perform).

It has been proven experimentally that, in case you change the DNA code in order that the glycine is substituted by an amino acid referred to as alanine (one additional methyl group), the enzyme turns into fully insensitive to glyphosate at any focus. It additionally takes a success on phosphate binding due to the additional methyl group, however you’ll be able to tweak one other amino acid close by to repair this drawback, whereas nonetheless retaining its insensitivity to glyphosate.

Researchers from Dow-Dupont did precisely this to a maize model of EPSP synthase utilizing CRISPR know-how and had been in a position to create synthetically a model of the maize’s personal EPSP synthase that was fully proof against glyphosate. The title of this paper is: “Desensitizing Plant EPSP Synthase to Glyphosate: Optimized World Sequence Context Accommodates a Glycine-to-Alanine Change within the Lively Web site.”2

The shikimate pathway is the pathway that produces fragrant amino acids, that are important to people as we can’t create these amino acids in our physique. The argument is we’re not prone to glyphosate as a result of our cells haven’t got EPSP synthase — the truth is, they do not have the complete shikimate pathway.

Nonetheless, our intestine microbes do have that pathway, they usually use it to make important amino acids for the host. So, our intestine microbes are certainly affected by glyphosate, and once they’re broken, our well being can endure in any variety of methods.

However what is likely to be an much more devastating drawback with glyphosate is the best way it in all probability messes up a lot of proteins that bind phosphate at a website the place there’s not less than one, and infrequently three, extremely conserved glycine residues. Glyphosate slips its methylphosphonate group into the spot that’s alleged to be the place phosphate from the substrate suits snugly. Phosphate cannot bind as a result of glyphosate is in the best way.

The arguments for why glyphosate particularly disrupts proteins that rely on glycine for phosphate binding are described extra totally in a paper Seneff revealed along with colleagues arguing that glyphosate is a significant factor in kidney failure amongst younger agricultural staff in Central America.3

The Significance of Deuterium

Laszlo Boros is a professor of pediatrics at UCLA and an knowledgeable on deutenomics, “the science of autonomic deuterium discrimination in nature.”4 After studying one in all Seneff’s papers, he contacted her, suggesting she look into deuterium.

“I used to be blown away, and I instantly noticed the connection to glyphosate,” she says. “This was a 12 months in the past in December, and I’ve simply been studying all the things I can on deuterium since then and hooking it to glyphosate. It is simply astonishing what I discovered, even, in the end, [linking it] to COVID-19.

It has been fairly a 12 months for me by way of main breakthroughs in my understanding of how metabolism works and the way it’s getting tousled by glyphosate, after which how that is inflicting us to not be capable to successfully cope with COVID-19.”

In regular physiology, your cells, particularly the mitochondria, perform to assist deplete your physique of deuterium. Deuterium is a naturally occurring isotope of hydrogen. When you did not already know, deuterium is also called heavy hydrogen, as a result of it has a neutron along with the proton and electron within the hydrogen atom.

Offered your cell is wholesome, it has deuterium-depleting enzymes and organelles that assist take away deuterium out of your cells. In case your mitochondria are broken by glyphosate, they are not going to have the ability to get rid of the deuterium correctly.

Deuterium is like iron in the best way that it is each important in the appropriate quantities and poisonous in extra. Hydrogen is the smallest atom and by far the most typical atom in your physique. Deuterium, being a heavy hydrogen, has one additional neutron, along with the traditional proton and electron that common hydrogen has.

Now, your cells are surrounded by structured water, which is negatively charged and contributes to your physique’s power manufacturing by supplying deuterium-depleted hydrogen to lysosomes and mitochondria. The structured water is maintained by sulfates, which makes sulfate extraordinarily necessary for well being. Sulfate is made dysfunctional by glyphosate, which in flip destroys structured water, leading to impaired power manufacturing within the cell.5

“The mitochondria have [a] membrane, which has a component contained in the membrane that is actually, actually necessary,” Seneff says. “That is the place you’ve gotten these protons, and you actually don’t desire it to be deuterons. That is what Laszlo introduced residence to me.”

How Your Physique Creates Deuterium-Depleted Water

Endothelial NOS (eNOS) makes nitric oxide (NO), and for each molecule of NO that it makes, it produces two molecules of water, that are deuterium depleted. Stephanie believes the NO created by eNOS could act as a sign that deuterium-depleted water has been created. Curiously sufficient, deuterium-depleted water can be created throughout the inflammatory course of.

“The irritation is there for a superb purpose, and the reason being to supply deuterium-depleted water,” Seneff says. “It is all as a result of the mitochondria are failing of their process of manufacturing their very own deuterium-depleted water, which they get partly by means of the structured water from the sulfate [and] by means of enzymes which are extremely expert at selecting hydrogen over deuterium …

NADH and NADPH are additionally fascinating. I have been chasing them by means of all of the proteins. They’re attention-grabbing as a result of they’re the carriers of that fantastic hydrogen that is not deuterium. Once you hint what’s doing what, the place, you understand that the cytoplasm is producing NADH and handing it over to the mitochondria.

The mitochondria then take that H [hydrogen atom] off and throw it into the intermembrane house. So, the entire course of finally ends up with the intermembrane house being assured that that is H [hydrogen] and never D [deuterium].

That is essential as a result of then these protons, as soon as they construct up, come again by means of the ATPase [ATP synthase] pump. If they’re deuterons, they will wreck the pump … You launch reactive oxygen species [that] break it, and naturally, then you’ll be able to’t make ATP.”

For clarification, the ATP synthase pump works like a mini-motor. When a hydrogen atom with one proton goes by means of it, it really works flawlessly and generates ATP. If deuterium enters it, which has one neutron and one proton, making it twice the burden of hydrogen, it breaks that motor.

Curiously, deuterium is all over the place, naturally, however your physique has developed an intricate technique to make it innocent by trapping it within the structured water, the place it is helpful, because it truly helps the creation of structured water.

Issues come up whenever you can’t make sufficient structured water to sequester all of it. Then, the deuterium will get unfastened, inflicting mitochondrial dysfunction, impairing power manufacturing and contributing to persistent illness.

Glyphosate Damages Well being in Many Methods

As famous by Seneff, glyphosate harms your well being in quite a lot of methods. For instance, she cites a latest paper displaying it causes endocrine disruption, which may result in breast most cancers, reproductive points, weight problems and thyroid issues.6

One other paper exhibits glyphosate sensitizes cells to be extra receptive to most cancers after publicity to different chemical substances.7 “Glyphosate makes all the things else extra poisonous than it might in any other case be,” Seneff says. “It disrupts your protection system towards poisonous chemical substances.” Different analysis exhibits epigenetic and generational results, even when no obvious issues may be discovered within the first technology uncovered.8

Glyphosate additionally impairs flavoproteins — proteins that bind flavins. Many of those proteins play an important position in transferring hydrogen from NADH or NADPH to different molecules, primarily supporting the supply of pure hydrogen to the mitochondria. Flavoproteins have a attribute GxGxxG motif on the website the place they bind phosphate within the flavins. The ‘G’ stands for glycine and the ‘x’ is a wildcard — any amino acid, together with glycine.

This implies they’ve not less than three prone glycines at this vital area of the protein. Flavoproteins are molecules that facilitate the switch of protons and electrons, and know the best way to keep away from deuterium, by exploiting a particular characteristic of hydrogen referred to as proton tunneling.

All of them may be anticipated to be disrupted by glyphosate. A vital flavoprotein is succinate dehydrogenase, and a number of other papers have proven it’s adversely affected by glyphosate, Seneff says. It’s the solely enzyme that performs a job in each oxidative phosphorylation and the citric acid cycle within the mitochondria.

Along with fragrant amino acids, the shikimate pathway is crucial for riboflavin synthesis, and riboflavin, a B vitamin, is the principle precursor to flavins. Which means riboflavin deficiency may be triggered from glyphosate publicity as effectively.
Glyphosate additionally causes harm by:

  • Rising calcium uptake in cells, which causes toxicity to neurons
  • Interfering with the flexibility to take glutamate out of your synapses
  • Making manganese unavailable — This in flip disrupts and prevents glutamate from being became unhazardous glutamine after it is eliminated out of your synapses. The enzyme answerable for the conversion can be extremely depending on glycine, which might be changed by glyphosate

Deuterium-Depleted Water Could Be Central to Metabolism

In line with Seneff, it seems deuterium-depleted water performs a central, hitherto unappreciated position in metabolism, as your physique has so some ways to create it. For instance, deuterium-depleted water is created by means of:

Fatty acid synthesis and metabolism — The enzymes that synthesize fatty acids incorporate hydrogen that’s carried by NADPH. This hydrogen atom has been rigorously chosen to be assured to not be deuterium. Curiously, lipoxygenase is a protein expressed throughout situations of stress, and based on Seneff, it has the best potential to pick out protons over deuterons of any protein.

It’s extremely upregulated in extreme COVID-19 an infection. It seems the virus triggers a rise in lipoxygenase as a result of the virus captures linoleic acid (LA) in pockets within the viral membrane. Nonetheless, lipoxygenase just isn’t a flavoprotein, and it additionally would not bind heme — this makes it resistant to break from glyphosate. So, its activation turns into an alternate pathway to repair the mitochondrial deuterium drawback.

SARS-CoV-2 picks up the omega-6 LA because it crosses the mobile membrane, and the LA then triggers the manufacturing of lipoxygenase that modifies the LA into leukotrienes — signaling molecules that herald damaging macrophages.

However deuterium-depleted water can be produced on this course of, by yanking two hydrogen atoms out of the fats and mixing them with oxygen to make water. Notice that that is simply one more means that extra LA damages your physique, however with an ulterior motive that we regularly fail to understand.

Sterol synthesis and metabolism — together with ldl cholesterol, vitamin D, cortisol, and intercourse hormones.

Fragrant amino acid derivatives — together with melatonin and neurotransmitters resembling dopamine and serotonin, in addition to thyroid hormone.

“All these molecules that undergo these sophisticated steps are all targeted on delivering deuterium-depleted water to the mitochondria,” Seneff says. “I imply, it is an absolute obsession that the cell has.” She goes on to evaluation how processes which will seem to don’t have anything however dangerous results are literally an effort to heal the physique. This, for instance, appears to be the case in COVID-19:

“I consider that no matter biology is doing, it is doing it for a superb purpose. There could also be harm, however there is a good purpose why you want that harm as a way to survive long run. It is attempting to repair an issue that is very critical, and that is what I feel is occurring with [SARS-CoV-2].

Not solely does it induce this lipoxygenase, which produces deuterium-depleted water, it then creates this inflammatory setting, which brings within the platelets and the macrophages, the immune cells and the stem cells. All these are having an enormous social gathering in there in all this fluid that is increase contained in the lungs.

In the meantime, it additionally will increase the manufacturing of hyaluronic acid. Hyaluronic acid is ready to lure deuterium-depleted water. It makes structured water. So, you get structured water contained in the alveoli of the lungs, and you then get fluid water within the interstitial areas.

The blood vessels are leaky, the capillaries are leaky. Every little thing’s popping out of the capillaries into this interstitial house the place there’s this fluid water, and you have got this lipoxygenase making deuterium-depleted water.

So, you are producing this setting of deuterium-depleted water, inviting the macrophages to return in, and the platelets launch their mitochondria … the stem cells additionally are available in and launch their mitochondria, after which macrophages sweep up the mitochondria — and all that is taking place within the interstitial house within the lungs the place the fluid is. Because of this you can’t breathe. You are drowning.

Perhaps one of the crucial necessary issues platelets do is cling on to mitochondria that they will ship to the macrophages below situations of stress. So, what occurs is all these mitochondria get launched in that interstitial house, and the macrophages induce this macropinocytosis, the place they really sweep up the water and all the things that is in it and produce it contained in the macrophage, together with the mitochondria.

It is truly been proven that platelets can launch mitochondria into the setting, and macrophages can take them up and use them as completely functioning mitochondria. It is astonishing. So, what they’re doing is restoring the mitochondrial well being to the immune cells.”

Glyphosate Harm Could Be a Think about Extreme COVID-19

As defined by Seneff, your immune cells are impaired by glyphosate, so the older you’re, the extra seemingly you’ve got been uncovered to glyphosate for many years and due to this fact have poorly functioning immune cells. Curiously, Seneff factors out that the comorbidities of COVID-19 — weight problems, diabetes and hypertension — are additionally illnesses whose prevalence goes up dramatically over time, precisely consistent with glyphosate utilization on core crops.

“So, I feel it is principally about glyphosate,” she says. “When you’ve gathered lots of glyphosate in your tissues, you are not going to do effectively with COVID-19, and that is as a result of [your body] is attempting to restore the mitochondria within the immune cells in order that the immune cells can truly clear the virus. If they cannot make ATP, they cannot do their job, and the virus prospers.”

The important thing take-home message right here is that that is but another excuse to scrub up your weight loss plan to ensure you’re not uncovered to glyphosate. It mainly wrecks your immune cells, and the cascading harm that takes place in extreme instances of COVID-19 seems to be your physique’s response to salvage or restore these poorly functioning immune cells.

Dietary Suggestions

The reply to this drawback is, to begin with, to eat licensed natural meals every time attainable. “We cannot purchase it if we will not discover licensed natural, and we have actually seen well being enhancements since we have began doing that,” Seneff says. “I actually swear by it, and I attempt to get all my pals to do the identical. I feel in case you can get rid of glyphosate, you’ll be able to actually see nice enhancements in your well being it doesn’t matter what your issues are.” Different dietary suggestions embrace consuming/ingesting extra:

Sulfur-containing meals resembling natural eggs and seafood

Natural grass fed milk and butter. Butter is without doubt one of the lowest deuterium meals obtainable

Glacier water, which is of course low in deuterium

Animal fat, that are additionally low in deuterium

Molecular hydrogen

Probiotics meals resembling sauerkraut and apple cider vinegar

To assist “push” glyphosate out of your physique and mitigate its toxicity, you’ll be able to take a cheap glycine complement. I take between 5 and 10 grams a day. It has a lightweight, candy style, so you’ll be able to truly use it as a sweetener.

“It is sensible as a result of it is mainly going to outnumber the glyphosate molecules,” Seneff says. “Bear in mind, glyphosate’s going to compete with glycine in constructing the protein. If there’s lots of glycine round, then it is a lot much less seemingly that glyphosate will get in there.”

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